{"id":415,"date":"2024-06-25T12:32:03","date_gmt":"2024-06-25T10:32:03","guid":{"rendered":"https:\/\/science.harbauerlab.de\/wordpress\/?p=415"},"modified":"2024-06-25T12:35:43","modified_gmt":"2024-06-25T10:35:43","slug":"pink-surfin-on-the-er","status":"publish","type":"post","link":"https:\/\/science.harbauerlab.de\/wordpress\/2024\/06\/25\/pink-surfin-on-the-er\/","title":{"rendered":"Pink surfin&#8217; on the ER"},"content":{"rendered":"\n<p>The ER plays an active role in the biogenesis of the #Parkinson protein PINK1 in stabilizing its precursor on its way to #mitochondria in neurons. #mitophagy New preprint from my lab on <a href=\"https:\/\/www.biorxiv.org\/content\/10.1101\/2024.06.21.600039v1\" title=\"\">BioRxiv<\/a>! <\/p>\n\n\n\n<p>Here Inma and Tabitha used the power of SunTag imaging to visualize where in a neuron PINK1 is being translated&#8230;and it turns out, that one organelle is not enough! PINK1 translation occurs at three-way contact sites between mitochondria, the ER and endolysosomes. And to find its way back to mitochondria, the PINK1 preprotein needs the help of ER-associated chaperones, as in the <a href=\"https:\/\/www.science.org\/doi\/10.1126\/science.aar8174\" title=\"\">ER-SURF<\/a> pathway described in yeast.  <\/p>\n\n\n<div class=\"wp-block-image is-style-rounded\">\n<figure class=\"aligncenter size-full\"><img loading=\"lazy\" decoding=\"async\" width=\"563\" height=\"561\" src=\"https:\/\/science.harbauerlab.de\/wordpress\/wp-content\/uploads\/2024\/06\/Presentation1.jpg\" alt=\"\" class=\"wp-image-416\" srcset=\"https:\/\/science.harbauerlab.de\/wordpress\/wp-content\/uploads\/2024\/06\/Presentation1.jpg 563w, https:\/\/science.harbauerlab.de\/wordpress\/wp-content\/uploads\/2024\/06\/Presentation1-300x300.jpg 300w, https:\/\/science.harbauerlab.de\/wordpress\/wp-content\/uploads\/2024\/06\/Presentation1-150x150.jpg 150w, https:\/\/science.harbauerlab.de\/wordpress\/wp-content\/uploads\/2024\/06\/Presentation1-75x75.jpg 75w\" sizes=\"auto, (max-width: 563px) 100vw, 563px\" \/><figcaption class=\"wp-element-caption\">A pink surfer on ER tubules, trying to make its way to mitochondria. Created with deepAI.org<\/figcaption><\/figure><\/div>","protected":false},"excerpt":{"rendered":"<p>The ER plays an active role in the biogenesis of the #Parkinson protein PINK1 in stabilizing its precursor on its way to #mitochondria in neurons. #mitophagy New preprint from my lab on BioRxiv! Here Inma and Tabitha used the power of SunTag imaging to visualize where in a neuron PINK1 is being translated&#8230;and it turns out, that one organelle is not enough! PINK1 translation occurs at three-way contact sites between mitochondria, the ER and endolysosomes. And to find its way back to mitochondria, the PINK1 preprotein needs the help of ER-associated chaperones, as in the ER-SURF pathway described in yeast.<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1],"tags":[],"class_list":["post-415","post","type-post","status-publish","format-standard","hentry","category-news"],"acf":[],"_links":{"self":[{"href":"https:\/\/science.harbauerlab.de\/wordpress\/wp-json\/wp\/v2\/posts\/415","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/science.harbauerlab.de\/wordpress\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/science.harbauerlab.de\/wordpress\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/science.harbauerlab.de\/wordpress\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/science.harbauerlab.de\/wordpress\/wp-json\/wp\/v2\/comments?post=415"}],"version-history":[{"count":2,"href":"https:\/\/science.harbauerlab.de\/wordpress\/wp-json\/wp\/v2\/posts\/415\/revisions"}],"predecessor-version":[{"id":419,"href":"https:\/\/science.harbauerlab.de\/wordpress\/wp-json\/wp\/v2\/posts\/415\/revisions\/419"}],"wp:attachment":[{"href":"https:\/\/science.harbauerlab.de\/wordpress\/wp-json\/wp\/v2\/media?parent=415"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/science.harbauerlab.de\/wordpress\/wp-json\/wp\/v2\/categories?post=415"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/science.harbauerlab.de\/wordpress\/wp-json\/wp\/v2\/tags?post=415"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}