Publications

Here is our contribution to science, the world and all the rest:

Original articles

Hees J.T*., Segura, I*, Schneider, A., Schifferer, M., Misgeld, T. and Harbauer, A.B. (2024) PINK1 protein biogenesis in neurons requires integration of signals from the ER and Endolysosomes to enable mitophagy. bioRxiv 2024.06.21.600039; doi: https://doi.org/10.1101/2024.06.21.600039. (*equal contribution)

Hees. J.T., Wanderoy, S., Lindner, J., Helms, J, Murali Mahadevan, H. and Harbauer, A.B. (2023) Insulin signaling regulates Pink1 mRNA localization via modulation of AMPK activity to support PINK1 function in neurons. Nat. Metab. 6, 514–530 (2024).

Harbauer, A. B.; Hees, J. T.; Wanderoy, S.; Segura, I.; Gibbs, W.; Cheng, Y.; Ordonez, M.; Cai, Z.; Cartoni, R.; Ashrafi, G. et al. (2022) Neuronal mitochondria transport Pink1 mRNA via synaptojanin 2 to support local mitophagy. Neuron 110 (9), S. 1516 – 1531.e9

Strohm, L.; Hu, Z.; Suk, Y.; Rühmkorf, A.; Sternburg, E.; Gattringer, V.; Riemenschneider, H.; Berutti, R.; Graf, E.; Weishaupt, J. H.; Brill, M.S.; Harbauer, A.B. et al. (2022) Multi-omics profiling identifies a deregulated FUS-MAP1B axis in ALS/FTD-associated UBQLN2 mutants. Life science alliance 5 (11), e202101327

Wanderoy, S., Rühmkorf, A., Harbauer, A. B. (2022). Microfluidics-Assisted Selective Depolarization of Axonal Mitochondria. J. Vis. Exp. (186), e64196, doi:10.3791/64196

Kravic B., Harbauer A.B., Romanello V., Simeone L., Vögtle F.-N., Kaiser T., Straubinger M., Huraskin D. Böttcher M.,  Cerqua C., Martin E. D., Poveda-Huertes D., Buttgereit A., Rabalski A. J., Heuss, D., Rudolf R., Friedrich, O., Litchfield D., Marber M., Salviati L., Mougiakakos D., Neuhuber W., Sandri M., Meisinger C., Hashemolhosseini S. (2018) In mammalian skeletal muscle, phosphorylation of TOMM22 by protein kinase CSNK2/CK2 controls mitophagy. Autophagy, 14(2), 311-335.

Harbauer, A.B., Opalińska, M., Herman, J.S., Rao, S., Guiard, B., Schmidt, O., Pfanner, N., and Meisinger, C. (2014) Cell cycle-dependent regulation of mitochondrial preprotein translocase. Science, 346(6213), 1109–13.

Gerbeth, C.*, Schmidt, O.*, Rao, S., Harbauer, A.B., Mikropoulou, D., Opalińska, M., et al. (2013). Glucose-Induced Regulation of Protein Import Receptor Tom22 by Cytosolic and Mitochondria-Bound Kinases. Cell Metabolism, 18, 578–587. (*equal contribution)

Rao, S., Schmidt, O., Harbauer, A.B., Schönfisch, B., Guiard, B., Pfanner, N., and Meisinger, C. (2012). Biogenesis of the preprotein translocase of the outer mitochondrial membrane: protein kinase A phosphorylates the precursor of Tom40 and impairs its import. Molecular Biology of the Cell 23, 1618–1627.

Rao, S.*, Gerbeth, C.*, Harbauer, A.B., Mikropoulou, D., Meisinger, C., and Schmidt, O.  (2011). Signaling at the gate: Phosphorylation of the mitochondrial protein import machinery. Cell Cycle 10, 2083-2090.

Schmidt, O.*, Harbauer, A.B.*, Rao, S., Eyrich, B., Zahedi, R.P., Stojanovski, D., Schönfisch, B., Guiard, B., Sickmann, A., Pfanner, N., and Meisinger, C. (2011). Regulation of mitochondrial protein import by cytosolic kinases. Cell 144, 227-239. (*equal contribution)

Review articles and book chapters

Rühmkorf, A. and Harbauer, A. B. (2023) Role of Mitochondria – ER Contact Sites in Mitophagy. Biomolecules 13 (8), 1198

Harbauer, A. B.; Schwarz, T. L. (2022) Mitochondrial hitch-hiking of Pink1 mRNA supports axonal mitophagy. Autophagy 1-2. doi: 10.1080/15548627.2022.2070332. Epub ahead of print.

Harbauer, A. B.; Schneider, A.; Wohlleber, D. (2022) Analysis of mitochondria by single-organelle resolution. Annual review of analytical chemistry 15, S. 1 – 16

Hees, J. T.; Harbauer, A. B.: Live-cell imaging of RNA transport in axons of cultured primary neurons. In: Axonal Transport. Methods and Protocols, 1 Aufl., S. 225 – 237 (Hg. Vagnoni, A.). Humana, New York (2022)

Heger, L. M.; Wise, R. M.; Hees, J. T.; Harbauer, A. B.; Burbulla, L. F.: (2021) Mitochondrial phenotypes in Parkinson’s diseases – A focus on human iPSC-derived dopaminergic neurons. Cells 10 (12), 3436

Murali Mahadevan, H., Hashemiaghdam, A., Ashrafi, G., and Harbauer, A.B. (2021). Mitochondria in Neuronal Health : From Energy Metabolism to Parkinson ’ s Disease. Adv. Biol. 2100663.

Wanderoy, S., Hees, J.T., Klesse, R., Edlich, F., and Harbauer, AB (2020). Kill one or kill the many: interplay between mitophagy and apoptosis. Biol. Chem. 402, 73–88.

Harbauer A.B. (2017) Mitochondrial health maintenance in axons. Biochem. Soc. Trans. 45, 1045–1052.

Harbauer, A.B., Zahedi, R.P., Sickmann, A., Pfanner, N., and Meisinger, C. (2014) The Protein Import Machinery of Mitochondria: a Regulatory Hub in Metabolism, Stress and Disease. Cell Metabolism, 19, 357–372.